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The Henderson family returning from vacation accidentally hits an eight foot Bigfoot and brings it home. They decide to nurse him, and end up letting him stay with them.
Harry's need for attention takes its toll on the Hendersons, especially George, who bigfoot-sits while preparing a work assignment.
Harry feels uncomfortable in the Henderson home so he decides to run away.
The family takes Harry back to the woods, only to discover that his home territory has been clearcut. Meanwhile, Ernie doesn't want Harry to go away. (Part 1 of 2)
A local congressman's (Steve Landesberg) aid is sought when Harry's (Kevin Peter Hall) habitat is found destroyed. The clan petitions to save the forest. (Part 2 of 2)
George's and Ernie's attitudes differ over a father-son baseball game. George recruits Ken Griffey Jr. in a plan to spark Ernie's interest in baseball. Guest Stars: Ken Griffey Sr., Ken Griffey Jr.
A British explorer, the son of a famous hunter, wants to outshine his father. In order to do that, he plans to bag Harry.
The Hendersons try to close down an animal research lab by protesting after finding an escapee, a scruffy dog, on their doorstep.
Harry and an American Indian medicine man try to cure George's knee but he is reckless.
The only doctor who can help a dying Harry is an elderly embittered anthropologist whose theories about Bigfoot were stamped out.
A bully (Aeryk Egan) steals Ernie's special pair of sneakers needed by George for a presentation. Ernie uses Harry's formidable size and strength in a plan to retrieve them.
Harry befriends a homeless intruder who reveals that he built the Hendersons' house. Meanwhile, the Hendersons are celebrating a birthday.
A football legend visits the Hendersons' house along with his wife who is wearing a fur. Harry thinks that the fur is a dead person and decides to bury it.
When Harry hides Nancy's diamond ring, the Hendersons ask a pet psychic (Michael Winslow) to read Harry's mind.
A monster-movie director (Pat Morita) wants permission from the Hendersons to use Harry in one of his films.
Harry becomes a wrestler to help Sarah raise money to save an injured sea lion. George asks wrestler 'Hacksaw' Jim Duggan to judge a benefit match featuring the debut of reluctant wrestler 'Bigfoot Man'.
When Tiffany brings Harry home, George and Nancy tell Samantha the truth, whetting her appetite for a good news story. Samantha decides to break the story of Harry on her news program.
When three Dallas Cowboy cheerleaders come to town on a mascot search, Ernie dreams that he loses his pal Harry to stardom. Ernie fears Harry may become the new mascot for the Dallas Cowboys cheerleaders.